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Developed by Vladislav Staroselskiy
CFMI Members
Andrea Gropman, M.D.
Position:Assistant Professor
Bio:
Dr. Gropman is a child neurologist and clinical geneticist. After completing her residency training in Pediatrics at Johns Hopkins Hospital , she completed fellowships in neurology and Child Neurology at George Washington University and the Children’s National Medical Center , and clinical genetics at the National Human Genome Research Institute. This was followed by a position as a Senior Staff Fellow in the Intramural Research Program at the National Institutes of Neurological Disorders and Stroke in Bethesda, MD where she was funded by a Howard Hughes Medical Institute physician postdoctoral award . During this time she was actively involved in basic research, in the study of genetic pathways involved in neuronal migration disorders, and participated as co-investigator and/or consultant for a number of clinical protocols in the NIH clinical center with the focus on neurologic phenotypes in neurometabolic and genetic disorders. She directed the neurogenetics clinic at the Children’s National Medical Center from 1997. In August of 2003, she joined the pediatrics and neurology faculty at Georgetown University . She currently directs the Neurodevelopmental clinic for the CFMI. Her area of interest is neurological phenotypes in children and adults with genetic and metabolic disorders.
Textbook Chapters
Gropman A and Packer R. (1998) "Pseudotumor cerebri" In: Klein, B Orenstein, and T Mayer (eds). Pediatric Emergencies on disk . CMC Research publications.
Gropman A and Packer R (1998) "Reyes Syndrome" In: Klein, B Orenstein, and T Mayer (eds). Pediatric Emergencies on disk. CMC Research publications.
Gropman A and Packer R (1998) "Reyes Syndrome" In: Klein, B Orenstein, and T Mayer (eds). Pediatric Emergencies on disk. CMC Research publications.
Smith ACM and Gropman A (2001). "Smith-Magenis syndrome" In: Cassidy S.B. and Allanson J (eds). Management of Genetic Syndromes. New York : Wiley-Liss, Inc.
Gropman A and Muenke M (2003). "Holoprosencephaly" In: Cassidy S.B. and Allanson J (eds). Management of Genetic Syndromes. New York : Wiley-Liss, Inc. (In press)
Smith ACM and Gropman A (2005). "Smith-Magenis syndrome" In: Cassidy, S.B. and Allanson J (eds). Management of Genetic Syndromes, 2nd edition. New York: Wiley-Liss, Inc., pp. 507-526.
Gropman A and Muenke M (2005). "Holoprosencephaly" In: Cassidy S.B. and Allanson J (eds). Management of Genetic Syndromes, 2nd edition. New York: Wiley-Liss, Inc., pp. 291-308.
Gropman AL and Vanderver A (2005). "Childhood mitochondrial disorders and other inborn errors of metabolism presenting with white matter disease" In: Broderick P.A., Rahni D.N., and Kolodny E.H. (eds). Bioimaging in Neurodegeneration. New York: Humana Press, Inc.
Online Chapter
Muenke M and Gropman A (January 2003) Holoprosencephaly Overview In: GeneReviews: Genetic Disease Online Reviews at GeneTests-GeneClinics [database online]. Copyright, University of Washington ,Seattle . Available at http://www.geneclinics.org.
Publications:
Epstein HT. Kaufman M, Saperstein, A, Frank D, et al. (1991) Strain Differences in Mouse Brain Weight Gain and Spatial Location Scores during postnatal development. Biology of the Neonate 59: 171-180.==break==Gropman AL , Barkovich AJ, Vezina LG, Packer RJ, Conry JA, and Dubovsky EC. (1997) Pediatric Presentation of Congenital Bilateral Perisylvian Syndrome (CBPS): Clinical and MRI Findings. Neuropediatrics 28: 198-203.==break==Gropman AL , Gaillard WD, Campbell P, and Charya S. (1998) Wernicke's Disease in a child due to self starvation. The Lancet 351(9117): 1704-1705.==break==Gropman A , Packer RJ, Jakacki R, Phillips P, et al. (1998) Treatment of the Diencephalic Syndrome with Chemotherapy: growth, tumor response and long-term tumor control. Cance r 83: 166-172.==break==Gropman A , Levin S, Yao L, Lin T, et al (2000). Unusual renal features of Lowe syndrome in a mildly affected boy. American Journal of Medical Genetics 95: 461-466.==break==Gropman A (2001). Diagnosis and Treatment of Mitochondrial disorders in Children. Current Neurology and Neuroscience Reports 1: 185-194.==break==Wagner KR, Hamed S, Hadley DW, Gropman AL , et al (2001). Gentamycin Treatment of Duchene and Becker Muscular Dystrophy due to nonsense mutations. Annals of Neurology 49:706-711.==break==Wong LJ, Dai P, Tan D, Lipson M, Grix A, Sifry-Platt M, Gropman A , Chen TJ (2001). Severe Lactic Acidosis caused by a novel frame-shift mutation in mitochondrial-encoded cytochrome c oxidize subunit II. Am J Med Genet 102(1): 95-99.==break==Wong LJ, Liang MH, Kwon J, Alper O, Bai R, and Gropman A (2002): A CF patient with two novel mutations in mitochondrial DNA: Mild disease led to delayed diagnosis of both disorders. Am J of Medical Genetics 113: 59-64.==break==Smith ACM, Gropman AL , Bailey-Wilson J, Goker-Alpan O, Elsea SH, Blancato J, Lupski JR, Potocki L (2002): Hypercholesterolemia in children with Smith-Magenis Syndrome: del (17)(p11.2p11.2) Genetics in Medicine 4: 118-125.==break==Pramatarova A, Ochalski P, Chen K, Gropman A , Myers S, and Howell BW (2003). Nck 2 interacts with tyrosine phosphorylated Disabled 1 and redistributes in Reelin-stimulated neurons (in Press, Journal of Neuroscience).==break==Ahmed ZM, Morell RJ, Riazuddin S, Gropman A , Shaukat S, Ahmed MM, Mohiddin SA, Fananapazir L, Caruso RC, Husnain T, Khan SN, Riazuddin S, Griffith AJ, Friedman TB, Wilcox ER (2003). Mutations of MYO6 are Associated with Recessive Deafness, DFNB37. Am. J. Hum Genet. 72: 1315-1322.==break==Pearl PL, Gibson KM, Acosta MT, Vezina LG, Theodore WH, Rogawski MA, Novotny EJ, Gropman A , Conry JA, Berry GT, Tuchman M (2003). Clinical spectrum of succinic semialdehyde dehydrogenase deficiency. Neurology. 13;60(9):1413-1417.==break==Gropman A , Chen TJ, Krasnewich D, Chernoff E, Tifft C, and Wong LJ C (2003). Variable Clinical Manifestation of Homoplasmic G14459A Mitochondrial DNA Mutation (in press, American Journal of Medical Genetics).==break==Gropman A (2003). Vigabatrin and Newer Interventions in Succinic Semialdehyde Dehydrogenase Deficiency . Ann Neurol 54(S6): S66-S72.==break==Gropman A and Batshaw ML (2003) Cognitive outcome in Urea cycle disorders (in press)
